• Philippe Azouvi, Idir Ghout, Eleonore Bayen, Emmanuelle Darnoux, Sylvie Azerad, Alexis Ruet, Claire Vallat-Azouvi, Pascale Pradat-Diehl, Philippe Aegerter, James Charanton, and Claire Jourdan.
• a Assistance Publique-Hôpitaux de Paris , Hôpital Raymond Poincaré, Service de Médecine Physique et de Réadaptation , Garches , France.
• Brain Inj. 2016 Jan 1; 30 (13-14): 1665-1671.

ObjectivesTo assess predictors and indicators of disability and quality-of-life 4 years after severe traumatic brain injury (TBI), using structural equation modelling (SEM).MethodsThe PariS-TBI study is a longitudinal multi-centre inception cohort study of 504 patients with severe TBI. Among 245 survivors, 147 patients were evaluated upon 4-year follow-up, and 85 completed the full assessment. Two outcome measures were analysed separately using SEM: the Glasgow Outcome Scale-extended (GOS-E), to measure disability, and the QOLIBRI, to assess quality-of-life. Four groups of variables were entered in the model: demographics; injury severity; mood and cognitive impairments; somatic impairments.ResultsThe GOS-E was directly significantly related to mood and cognition, injury severity, and somatic impairments. Age and education had an indirect effect, mediated by mood/cognition or somatic deficiencies. In contrast, the only direct predictor of QOLIBRI was mood and cognition. Age and somatic impairments had an indirect influence on the QOLIBRI.ConclusionAlthough this study should be considered as explorative, it suggests that disability and quality-of-life were directly influenced by different factors. While disability appeared to result from an interaction of a wide range of factors, quality-of-life was solely directly related to psycho-cognitive factors.

36 keywords...

hide…