• Florin G Horhat, Alexandru F Rogobete, Marius Papurica, Dorel Sandesc, Sonia Tanasescu, Victor Dumitrascu, Monica Licker, Razvan Nitu, Carmen A Cradigati, Mirela Sarandan, Ovidiu Boruga, Ciprian D Crisan, Emil Ungureanu, Daniela M Popa, Sonia E Popovici, and Ovidiu H Bedreag.
• Clin Lab. 2016 Sep 1; 62 (9): 1601-1607.

BackgroundThe critically ill polytrauma patient, apart from the primary, traumatic injuries and the secondary, port-traumatic injuries, presents with a series of molecular disasters. Dysfunctions of the biochemical pathways and molecular damage add to the worsening of the clinical status of these patients, one of the most well-known molecular phenomena being oxidative stress (OS), responsible for an escalation of the inflammatory status, multiple infections, and multiple organ dysfunction syndrome (MODS).MethodsFor this study was analysed the literature available on PubMed and Scopus. The key words used in the search were "oxidative stress", "lipid peroxidation", "critically ill", "polytrauma patients", and "biomarkers oxidative stress".ResultsFor the study we selected 47 science articles. The oxidative attack on lipids is responsible for the biosynthesis of an increased quantity of free radicals (FR), which further intensifies and aggravates the redox status in these patients.ConclusionsOne of the most aggressive redox mechanisms related to lipid molecules is known as lipid peroxidation (LPOX).

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