-
Scand. J. Infect. Dis. · Jan 2009
Sensitivities to biocides and distribution of biocide resistance genes in quaternary ammonium compound tolerant Staphylococcus aureus isolated in a teaching hospital.
- Qingzhong Liu, Meina Liu, Qing Wu, Chao Li, Tieli Zhou, and Yuxing Ni.
- Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai.
- Scand. J. Infect. Dis. 2009 Jan 1; 41 (6-7): 403-9.
AbstractIn this study, the minimum bactericidal concentrations (MBCs) of 5 biocides (benzalkonium chloride, glutaraldehyde, sodium hypochlorite, povidone iodine and ethanol) for 56 clinical quaternary ammonium compound (QAC) tolerant S. aureus strains following exposure for 5, 30 or 180 min, collected from a teaching hospital in China, were examined. The distributions of the biocide resistance genes qacA/B, smr, qacH and qacG were investigated by polymerase chain reaction. Following 5 min exposure of benzalkonium chloride and povidone iodine, 7.1% (4/56) and 7.1% (4/56) isolates, respectively, exhibited MBC values higher than their in-use concentrations for mucosa and wound disinfection. The MBC values of all the isolates studied for glutaraldehyde, sodium hypochlorite and ethanol were lower than the in-use concentrations in all contact times. The qacA/B gene was found in 94.6% (53/56) of QAC tolerant S. aureus. The frequencies of smr (3.6%, 2/56) and qacH (7.1%, 4/56) were low and qacG was not detected. The results suggested that clinical QAC tolerant S. aureus isolates of China had the possibility to survive in proper in-use concentrations of some biocides at proper contact time, and qacA/B is the most prevalent disinfectant resistant gene in this type of bacteria.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.