• Bruce L Rollman, Bea Herbeck Belnap, Sati Mazumdar, Patricia R Houck, Fang Zhu, William Gardner, Charles F Reynolds, Herbert C Schulberg, and M Katherine Shear.
• Division of General Internal Medicine, Center for Research on Health Care, Department of Psychiatry, University of Pittsburgh School of Medicine, 230 McKee Place, Pittsburgh, PA 15213, USA. rollmanbl@upmc.edu
• Arch Gen Psychiat. 2005 Dec 1; 62 (12): 1332-41.

ContextPanic disorder and generalized anxiety disorder are prevalent in primary care, associated with poor functional outcomes, and are often unrecognized and ineffectively treated by primary care physicians.ObjectiveTo examine whether telephone-based collaborative care for panic and generalized anxiety disorders improves clinical and functional outcomes more than the usual care provided by primary care physicians.DesignRandomized controlled trial.SettingFour Pittsburgh area primary care practices linked by a common electronic medical record system. Patients A total of 191 adults aged 18 to 64 years with panic and/or generalized anxiety disorder who were recruited from July 2000 to April 2002. Intervention Patients were randomly assigned to a telephone-based care management intervention (n = 116) or to notification alone of the anxiety disorder to patients and their physicians (usual care, n = 75). The intervention involved non-mental health professionals who provided patients with psychoeducation, assessed preferences for guideline-based care, monitored treatment responses, and informed physicians of their patients' care preferences and progress via an electronic medical record system under the direction of study investigators.Main Outcome MeasuresIndependent blinded assessments of anxiety and depressive symptoms, mental health-related quality of life, and employment status at baseline, 2-, 4-, 8-, and 12-month follow-up.ResultsAt 12-month follow-up, intervention patients reported reduced anxiety (effect size [ES], 0.33-0.38; 95% confidence interval [CI], 0.04 to 0.67; PConclusionsTelephone-based collaborative care for panic disorder and generalized anxiety disorder is more effective than usual care at improving anxiety symptoms, health-related quality of life, and work-related outcomes.

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