Arch Gen Psychiat
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Randomized Controlled Trial Comparative Study
A randomized trial to improve the quality of treatment for panic and generalized anxiety disorders in primary care.
Panic disorder and generalized anxiety disorder are prevalent in primary care, associated with poor functional outcomes, and are often unrecognized and ineffectively treated by primary care physicians. ⋯ Telephone-based collaborative care for panic disorder and generalized anxiety disorder is more effective than usual care at improving anxiety symptoms, health-related quality of life, and work-related outcomes.
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Meta Analysis Comparative Study
Dropout rates in placebo-controlled and active-control clinical trials of antipsychotic drugs: a meta-analysis.
Dropout rates in randomized clinical trials of antipsychotic drugs have consistently been reported to be high, and the use of a placebo-controlled design is hypothesized to be one of the reasons for this. ⋯ Use of a placebo-controlled design had a major effect on the dropout rates observed. Because high dropout rates affect the generalizability of such studies, it is suggested that, in addition to the PCTs, studies with alternative designs need to be considered when evaluating an antipsychotic's clinical profile.