• Bull. Exp. Biol. Med. · Aug 2003

    Activity of the hypothalamic-pituitary-adrenocortical system and sleep-wake cycle in rats with acute systemic inflammation.

    • M I Eliava, V V Grinevich, and G A Oganesyan.
    • I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. m_eliava@hotmail.com
    • Bull. Exp. Biol. Med. 2003 Aug 1;136(2):110-3.

    AbstractActivity of the hypothalamic-pituitary-adrenocortical system and EEG characteristics of the sleep-wake cycle were studied on adult male Wistar rats with acute inflammation produced by bacterial lipopolysaccharide in a dose of 250 microg/100 g body weight. Blood concentrations of adrenocorticotropic hormone and corticosterone increased by 6 and 10 times, respectively, 30 min after lipopolysaccharide administration and peaked 2 hours after challenge. In this period the sleep-wake cycle underwent the most pronounced changes that could be attributed to the stupor-like state observed in clinical practice. It was manifested in dissociation between locomotor activity of animals and EEG characteristics, suppression of EEG components in slow-wave sleep, increase in the number of beta-waves, and decrease in the number of delta-waves in EEG. In the present work we consider possible mechanisms of temporal relationships between activity of the hypothalamic-pituitary-adrenocortical system and disorganization of the sleep-wake cycle during acute systemic inflammation.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

Want more great medical articles?

Keep up to date with a free trial of metajournal, personalized for your practice.
1,694,794 articles already indexed!

We guarantee your privacy. Your email address will not be shared.