• Saudi Med J · Jul 2021

    Association between sex hormones and migraine in young Saudi females.

    • Lubna I Al Asoom, Modhi S Alajmi, Reem R Alsudairi, Abeer A AlShamlan, Amal A Almomaten, Asma A Alqarni, Manal H Alshammari, Nazish Rafique, Rabia Latif, Ahmed A Alsunni, Dana A Almohazey, Hind S Alsuwat, Sayed Abdul Azeez, and Francis J Borgio.
    • From the Department of Physiology (Al Asoom, Rafique, Latif, Alsunni); from the College of Medicine (Alajmi, Alsudairi, AlShamlan, Almomaten, Alqarni, Alshammari); from the Department of Stem Cell Research (Almohazey); and from the Department of Genetic Research (Alsuwat, AbdulAzeez, Borgio), Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia.
    • Saudi Med J. 2021 Jul 1; 42 (7): 793-797.

    ObjectivesTo assess the sex hormone levels in young Saudi female migraineurs during a migraine attack and during pain-free periods and compare them with control subjects.MethodsA case-control study involving 14 Saudi female migraineurs and 21 control subjects was conducted between December 2019 and March 2020. Demographic and disease history data were collected through participant interviews. Blood samples were drawn during the migraine attack and pain-free periods.ResultsFollicular (30.00±19.60; p<0.001) and luteal (39.79±11.45; p=0.037) estrogen levels were significantly higher in patients with non-menstrual related migraine (NMM), while luteal testosterone levels (1.10±0.31; p=0.023) were significantly higher in patients with menstrually related migraine (MM). Body mass index (BMI) was higher in patients with NMM (25.77±6.53; p=0.013), and it was found to be associated with follicular estrogen (p=0.016), progesterone (p=0.018), and pain intensity (p=0.042). Luteal estrogen level was significantly lower (13.96±7.88; p=0.036) in patients with luteal onset of attack.ConclusionHigh estrogen levels were found to mediate NMM, their effect being more pronounced with increase in BMI; whereas low luteal estrogen levels mediated MM. Young females with MM might have high luteal testosterone levels, and a compensatory protective role could be surmised accordingly.Copyright: © Saudi Medical Journal.

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