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Acta clinica Croatica · Jun 2020
Case ReportsEffect of Methimazole Therapy on Thyroid Pathohistology That May Mimic Thyroid Malignancy.
- Ante Punda, Ana Barić, Zaviša Čolović, Mirko Kontić, Hrvoje Punda, and Valdi Pešutić Pisac.
- 1University Hospital of Split, Nuclear medicine department, Split, Croatia; 2University Hospital of Split, ENT department, Split, Croatia; 3University Hospital of Split, Radiology department, Split, Croatia; 4University Hospital of Split, Department for pathology, Split, Croatia.
- Acta Clin Croat. 2020 Jun 1; 59 (Suppl 1): 146-148.
AbstractDiffuse toxic goiter, as the most common cause of hyperthyroidism, is usually initially treated with thyrostatic drugs such as methimazole, followed by radioiodine therapy or surgery which may be indicated as definitive treatment. Radioactive iodine therapy has a known association with various histopathologic features including cytologic atypia, but herein we present a rare example of morphological thyrocyte changes induced by long-term pharmacological treatment with methimazole that mimicked thyroid malignancy in a pathohistological sample.
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