• IEEE Trans Med Imaging · Feb 2008

    A surface-based approach to quantify local cortical gyrification.

    • Marie Schaer, Meritxell Bach Cuadra, Lucas Tamarit, François Lazeyras, Stephan Eliez, and Jean-Philippe Thiran.
    • Service Médico-Pédagogique, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland. marie.schaer@medecine.unige.ch
    • IEEE Trans Med Imaging. 2008 Feb 1; 27 (2): 161-70.

    AbstractThe high complexity of cortical convolutions in humans is very challenging both for engineers to measure and compare it, and for biologists and physicians to understand it. In this paper, we propose a surface-based method for the quantification of cortical gyrification. Our method uses accurate 3-D cortical reconstruction and computes local measurements of gyrification at thousands of points over the whole cortical surface. The potential of our method to identify and localize precisely gyral abnormalities is illustrated by a clinical study on a group of children affected by 22q11 Deletion Syndrome, compared to control individuals.

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