• Tong-Zeng Li, Zhen-Huan Cao, Yu Chen, Miao-Tian Cai, Long-Yu Zhang, Hui Xu, Jia-Ying Zhang, Chun-Hua Ma, Yang Liu, Li-Juan Gao, Zhong-Hui Duan, Dan-Lei Mou, and Lian-Chun Liang.
• Department of Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China.
• J. Med. Virol. 2021 Jan 1; 93 (1): 506-512.

AbstractTo investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding. The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5°C), and time from onset to hospitalization were associated with prolonged duration of viral shedding (P < .05). Multivariate regression analysis showed that fever (temperature>38.5°C) (OR, 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR, 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR, 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding. Corticosteroid treatment, fever (temperature>38.5°C), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients.© 2020 Wiley Periodicals LLC.

21 keywords...

hide…