• Yue Li, Li Sheng, Weimin Li, Wei Liu, Yongtai Gong, Hongjie Xue, and Hongbo Shan.
• The First Clinical Hospital of Harbin Medical University, Harbin 150001, China.
• Biochem. Biophys. Res. Commun. 2009 Apr 3; 381 (2): 198-203.

AimsOxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling.MethodsTwenty dogs were randomly divided into sham-operated, control, and probucol-treated groups. We identified apoptosis and histopathological changes in the atria. Oxidative stress was measured by lipid peroxidation and echocardiographic examinations were performed.ResultsAtrial apoptosis indexes were dramatically decreased in the probucol-treated group compared to the control group. Relative to the control group, the percentage of myolysis was dramatically decreased in the probucol-treated group (p < 0.01). There was less lipid peroxidation in the probucol-treated group than the control group. Atrial function was dramatically elevated in the probucol-treated group.ConclusionsThe results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.

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