Biochemical and biophysical research communications
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Biochem. Biophys. Res. Commun. · Apr 2009
Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.
Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling. ⋯ The results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.