• Anderanik Tomasian, Mayil S Krishnam, Derek G Lohan, Abbas N Moghaddam, and J Paul Finn.
• Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, California 90095-7206, USA. atomasian@mednet.ucla.edu
• Invest Radiol. 2009 Jan 1; 44 (1): 31-7.

PurposeTo determine the potential role of dynamic temporally resolved three dimensional (3D) contrast-enhanced magnetic resonance angiography (MRA) for quantitative evaluation of pulmonary perfusion in adult patients with surgically treated Tetralogy of Fallot (ToF).Materials And MethodsInstitutional review board approval and written informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant study. Thirty consecutive patients with surgically repaired ToF and 30 age-matched controls underwent breath-hold 3D time-resolved MRA (TR-MRA) and single-phase high-resolution 3D MRA of the thorax at 1.5 T. Two readers evaluated both datasets for image quality and findings. On TR-MRA datasets, regions-of-interest were placed over main pulmonary artery and lung fields obtaining signal intensity time curves. Using analytic software, time-to-peak (TTP), mean transit time (MTT), maximal signal intensity (MSI), maximum upslope of the curve (MUS), pulmonary blood volume (PBV), and pulmonary blood flow (PBF) were calculated. Pulmonary radionuclide scintigraphy was available for a subgroup of patients with ToF (n = 12).ResultsFor ToF patients with unilateral pulmonary artery (PA) stenosis, TTP, and MTT were significantly longer, and MSI, MUS, PBV, and PBF were significantly lower in the ipsilateral lung compared with control subjects (P < 0.001 for all). There was no significant difference in TTP, MTT, MSI, MUS, PBV, and PBF between ToF patients without postsurgical stenotic residua and control subjects (P > 0.05 for all), nor between the mentioned perfusion indices for the contralateral lung in ToF patients with unilateral PA stenosis and control subjects (P > 0.05 for all). In ToF, patient with unilateral PA stenosis, analysis of contralateral-to-ipsilateral lung perfusion ratios on radionuclide scintigraphy and TR-MRA revealed significant correlation (r = 0.96). Bland-Altman plot showed a mean difference of 2.2% between the measured ratios (limits of agreement; -7.6%-12.0%).ConclusionTime-resolved 3D contrast-enhanced MRA has potential for noninvasive and quantitative assessment of altered patterns of pulmonary perfusion in adult ToF, and may be a reliable technique for evaluation of postsurgical residua in these patients.

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