Investigative radiology
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Investigative radiology · Jan 2009
Rapid whole-brain magnetic resonance imaging with isotropic resolution at 3 Tesla.
Isotropic imaging offers the potential of improving lesion detection and imaging efficiency by enabling orthogonal image reformations without loss of spatial resolution. However, lengthy scan times for T1-weighted isotropic data acquisitions have been an impediment to the routine clinical application of this approach. We tested the feasibility of using the improved signal-to-noise ratio at 3 Tesla to perform rapid, whole-brain T1-weighted imaging with isotropic 0.8 mm x 0.8 mm x 0.8 mm (0.51 mm3) voxels. ⋯ Artifacts were minimal, especially compared with 2D SE, whereas CNR was 2-fold better than SPGR-IR. The capability for creating reformatted images in orthogonal orientations from a single isotropic acquisition greatly improves efficiency compared with 2D acquisitions acquired in multiple planes. Although further clinical study is needed in a larger patient cohort, these initial results suggest substantial clinical promise for the technique.
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Investigative radiology · Jan 2009
Clinical TrialAdult Tetralogy of Fallot: quantitative assessment of pulmonary perfusion with time-resolved three dimensional magnetic resonance angiography.
To determine the potential role of dynamic temporally resolved three dimensional (3D) contrast-enhanced magnetic resonance angiography (MRA) for quantitative evaluation of pulmonary perfusion in adult patients with surgically treated Tetralogy of Fallot (ToF). ⋯ Time-resolved 3D contrast-enhanced MRA has potential for noninvasive and quantitative assessment of altered patterns of pulmonary perfusion in adult ToF, and may be a reliable technique for evaluation of postsurgical residua in these patients.