• Liuqing Liu, Fang Yang, Yan Jing, and Ling Xin.
• First Clinical Medical School of Beijing University of Chinese Medicine, Beijing 100700, China.
• J Tradit Chin Med. 2019 Jun 1; 39 (3): 440-450.

ObjectiveTo research the Traditional Chinese Medicine (TCM) practice of Professor Xu Runsan for treatment of chronic pelvic pain (CPP) caused by sequelae of pelvic inflammatory disease (SPID) by data mining.MethodsThe medical records of inpatients at China-Japan Friendship Hospital confirmed to have CPP caused by SPID were collected (274 visits in total). The data extracted from the medical records were analyzed by frequency statistics, correlation analyses, cluster analyses, and complex network analyses.ResultsThe most frequently used medicines were warm medicines, bitter medicines, and medicines distributed to the liver meridian. The most common medicinal combinations were Chishao (Radix Paeoniae Rubra) plus Huangqi (Radix Astragali Mongolici) plus Sanqi (Radix Notoginseng) and Ezhu (Rhizoma Curcumae Phaeocaulis); Guizhi (Ramulus Cinnamomi) plus Fuling (Poria) and Chishao (Radix Paeoniae Rubra); and Chaihu (Radix Bupleuri Chinensis) plus Zhishi (Fructus Aurantii Immaturus) and Gancao (Radix Glycyrrhizae). The most frequently used medicines were divided into four groups according to their efficacy; i.e., medicines that could (a) warm meridians and free collateral vessels, (b) regulate Qi and free collateral vessels, (c) fortify the spleen and nourish blood and Qi, and (d) tonify Qi and activate blood. The most commonly used formulations were Guizhi FulingPill and Sini Powder. The core medicines extracted based on complex network analyses were Chishao (Radix Paeoniae Rubra), Sanqi (Radix Notoginseng), Huangqi (Radix Astragali Mongolici), Danshen (Radix Salviae Miltiorrhizae), Ezhu (Rhizoma Curcumae Phaeocaulis), Gancao (Radix Glycyrrhizae), Chaihu (Radix Bupleuri Chinensis), Guizhi (Ramulus Cinnamomi), Shuizhi (Hirudo), Fuling (Poria), and Zhishi (Fructus Aurantii Immaturus).ConclusionAccording to the TCM practice of Professor Xu, treatment of CPP caused by SPID should focus on dissolving stasis and obstructionsusing medicines that can activate blood, resolve stasis, regulate Qi, and dissipate adhesions. His prescriptions are often based on Guizhi Fuling Pill and Sini Powder. More blood-activating, stasis-resolving, or tonifying medicines could be used according to the accompanying symptoms or symptom patterns identified.

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