• Ilkay S Idilman, Onur Keskin, Azim Celik, Berna Savas, Atilla Halil Elhan, Ramazan Idilman, and Musturay Karcaaltincaba.
• Hacettepe University, School of Medicine, Department of Radiology, Liver Imaging Team, Ankara, Turkey.
• Acta Radiol. 2016 Mar 1; 57 (3): 271-8.

BackgroundMany imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited.PurposeTo compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD.Material And MethodsA total of 19 NAFLD patients underwent MRI-PDFF, MRS, and liver biopsy for quantification of liver fat content. The MR examinations were performed on a 1.5 HDx MRI system. The MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling and MRS with STEAM technique.ResultsA close correlation was observed between liver MRI-PDFF- and histology- determined steatosis (r = 0.743, P < 0.001) and between liver MRS- and histology-determined steatosis (r = 0.712, P < 0.001), with no superiority between them (ƶ = 0.19, P = 0.849). For quantification of hepatic steatosis, a high correlation was observed between the two MRI methods (r = 0.986, P < 0.001). MRI-PDFF and MRS accurately differentiated moderate/severe steatosis from mild/no hepatic steatosis (P = 0.007 and 0.013, respectively), with no superiority between them (AUCMRI-PDFF = 0.881 ± 0.0856 versus AUCMRS = 0.857 ± 0.0924, P = 0.461).ConclusionBoth MRI-PDFF and MRS can be used for accurate quantification of hepatic steatosis.© The Foundation Acta Radiologica 2015.

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