• Yan Epelboym, Michael S Stecker, Chieh-Min Fan, Timothy P Killoran, Dmitry J Rabkin, and Matthew P Schenker.
• Brigham and Women's Hospital, Harvard Medical School, Department of Radiology, Division of Angiography and Interventional Radiology, 75 Francis Street, Boston, MA, USA 02356. Electronic address: yepelboym@bwh.harvard.edu.
• Clin Imaging. 2020 Feb 1; 59 (2): 95-99.

Rationale And ObjectivesMalignant obstruction of the IVC can cause severe morbidity and impairment of quality of life in end-stage oncology patients. However, medical literature regarding minimally-invasive palliation using large diameter percutaneous stents, particularly the Gianturco-Rosch-Z (GRZ) stent is limited.Materials & MethodsA retrospective review from January 2004 to February 2017, revealed 17 subjects with malignant obstruction of the IVC who were treated with a total of 34 GRZ stents. Pre- and post-stent pressure gradients were measured in 10. Available data regarding clinical presentation and follow-up were recorded.ResultsTechnical success for stent deployment was 100%. A median of 2 stents (range 1 to 5) were deployed per patient, with median stent diameter 20 mm (range 15 to 30 mm). The median pre-treatment pressure gradient of 17.5 mmHg (range 9-31 mmHg) decreased to a median of 4.5 mmHg (range 0-21 mmHg, p < .0004) after stent placement. One subject developed recurrent stent occlusion due to disease progression requiring additional intervention, for a primary patency rate of 94%. Lower extremity edema improved or resolved in 58% of those for whom follow-up data was recorded. Median survival after treatment was only 28 days (range 5 to 607 days). There were no procedural complications.ConclusionEndovascular treatment of malignant IVC obstruction can be safely performed with GRZ stents. Although overall survival is poor, this technique can effectively palliate lower extremity edema symptoms.Copyright © 2019 Elsevier Inc. All rights reserved.

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