• Pediatric radiology · Nov 2015

    Case Reports

    Isolated thymic Langerhans cell histiocytosis discovered on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT).

    • Sophie Turpin, Anne-Sophie Carret, Josée Dubois, Chantal Buteau, and Natalie Patey.
    • Nuclear Medicine, CHU Sainte-Justine, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, H3T 1C5, Canada. turpinsop@hotmail.com.
    • Pediatr Radiol. 2015 Nov 1; 45 (12): 1870-3.

    AbstractThe thymic infiltration in young patients with multisystemic Langerhans cell histiocytosis and its radiologic features are well known. However, isolated thymic disease has seldom been reported in the literature. We report the case of a 10-month-old child admitted for fever of unknown origin. Whole-body F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) was performed to identify a focus of infection. It demonstrated an unusual aspect of the thymus, which led to further investigation and revealed isolated infiltration of the thymus by Langerhans cell histiocytosis. The patient was treated accordingly and is now disease free. As evaluation of Langerhans cell histiocytosis patients with F-18 FDG PET/CT is becoming more frequent, it is important to be aware of the scintigraphical characteristics of thymic Langerhans cell histiocytosis.

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