• H Chih-ho Hong, Mark Lupin, and Kathryn F O'Shaughnessy.
• Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada. chihho@interchange.ubc.ca
• Dermatol Surg. 2012 May 1; 38 (5): 728-35.

BackgroundA third-generation microwave-based device has been developed to treat axillary hyperhidrosis by selectively heating the interface between the skin and underlying fat where the sweat glands reside.Materials And MethodsThirty-one (31) adults with primary axillary hyperhidrosis were enrolled. All subjects had one to three procedure sessions over a 6-month period to treat both axillae fully. Efficacy was assessed using the Hyperhidrosis Disease Severity Scale (HDSS), gravimetric weight of sweat, and the Dermatologic Life Quality Index (DLQI), a dermatology-specific quality-of-life scale. Subject safety was assessed at each visit. Subjects were followed for 12 months after all procedure sessions were complete.ResultsAt the 12-month follow-up visit, 90.3% had HDSS scores of 1 or 2, 90.3% had at least a 50% reduction in axillary sweat from baseline, and 85.2% had a reduction of at least 5 points on the DLQI. All subjects experienced transient effects in the treatment area such as swelling, discomfort, and numbness. The most common adverse event (12 subjects) was the presence of altered sensation in the skin of the arm that resolved in all subjects.ConclusionThe device tested provided efficacious and durable treatment for axillary hyperhidrosis.© 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

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