• Future microbiology · Jul 2018

    Meropenem-vaborbactam: a new weapon in the war against infections due to resistant Gram-negative bacteria.

    • Twisha S Patel, Jason M Pogue, John P Mills, and Keith S Kaye.
    • Department of Pharmacy Services, Michigan Medicine, Ann Arbor, MI 48109, USA.
    • Future Microbiol. 2018 Jul 1; 13: 971-983.

    AbstractMeropenem-vaborbactam is a fixed-dose combination product of a carbapenem and a cyclic boronic acid β-lactamase inhibitor with potent in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE). The efficacy of meropenem-vaborbactam for the treatment of complicated urinary tract infections and acute pyelonephritis was demonstrated in a Phase III trial (TANGO I). Preliminary data from TANGO II, a separate Phase III study, support the efficacy of meropenem-vaborbactam for the treatment of infections caused by CRE. Overall, meropenem-vaborbactam appears to be safe and well tolerated. It has favorable toxicity, pharmacokinetic and pharmacodynamic profiles compared with other antibiotics with activity against CRE. Meropenem-vaborbactam is an important addition to the current armamentarium of antimicrobial agents with activity against K. pneumoniae carbapenemase-producing CRE.

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