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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Randomized Controlled TrialInfluence of interfraction interval on local tumor control in patients with limited-disease small-cell lung cancer treated with radiochemotherapy.
- Branislav Jeremić and Biljana Milićić.
- Department of Oncology, University Hospital, Kragujevac, Serbia. b.jeremic@iaea.org
- Int. J. Radiat. Oncol. Biol. Phys. 2007 Jun 1; 68 (2): 426-32.
PurposeTo investigate the influence of interfraction interval (IFI) on local recurrence-free survival (LRFS) in patients with limited-disease small-cell lung cancer (LD SCLC) treated with accelerated hyperfractionated radiotherapy (Acc Hfx RT) and concurrent cisplatin and etoposide (PE).Methods And MaterialsA total of 103 patients were treated with either "early" (Cycle 1) or "late" (Cycle 4) concurrent Acc Hfx RT/PE. Two daily fractions were nonrandomly given using an IFI of either 4.5-5.0 h ("shorter") (n = 52) or 5.5-6.0 h ("longer") (n = 51).ResultsThe median LRFS and 5-year LRFS rate for all 103 patients were 52 months and 48%, respectively. Besides gender, Karnofsky performance status, and treatment group, IFI also influenced LRFS, whereas age and weight loss did not. When a multivariate model was used, IFI was marginally insignificant (p = 0.0770) as a predictor of LRFS. In terms of individual treatment groups, IFI was not significant in "early" Acc Hfx RT/PE but showed a strong trend in a "late" Acc Hfx RT/PE regimen. Although a shorter IFI led to a higher incidence of high-grade (>or=3) esophagitis, leukopenia, and infection, a correlation analysis of toxicities with all potential prognostic factors showed that a shorter IFI was not an independent predictor of any acute high-grade toxicity.Conclusion"Shorter" IFI had a marginally insignificant influence on LRFS. A strong trend favoring it was observed in patients treated with "late" concurrent Acc Hfx RT/PE. This may be of interest because it could contribute to further understanding of potential biologic parameters influencing treatment outcome.
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