International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Comparative StudyKilo-voltage cone-beam computed tomography setup measurements for lung cancer patients; first clinical results and comparison with electronic portal-imaging device.
Kilovoltage cone-beam computed tomography (CBCT) has been developed to provide accurate soft-tissue and bony setup information. We evaluated clinical CBCT setup data and compared CBCT measurements with electronic portal imaging device (EPID) images for lung cancer patients. ⋯ Use of CBCT scans provided more accurate information concerning the setup of lung cancer patients than did portal imaging.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Automatic segmentation of pelvic structures from magnetic resonance images for prostate cancer radiotherapy.
Target-volume and organ-at-risk delineation is a time-consuming task in radiotherapy planning. The development of automated segmentation tools remains problematic, because of pelvic organ shape variability. We evaluate a three-dimensional (3D), deformable-model approach and a seeded region-growing algorithm for automatic delineation of the prostate and organs-at-risk on magnetic resonance images. ⋯ Our results show that the organ-model method is robust, and results in reproducible prostate segmentation with minor interactive corrections. For automatic bladder and rectum delineation, magnetic resonance imaging soft-tissue contrast enables the use of region-growing methods.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Randomized Controlled Trial Multicenter StudyLumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer.
In women with favorable early breast cancer treated by lumpectomy plus tamoxifen or anastrazole, it remains unclear whether whole breast radiotherapy is beneficial. ⋯ Breast radiotherapy +/- boost in women with favorable early breast cancer after lumpectomy combined with tamoxifen/anastrazole leads to a significant reduction in local and overall relapse.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation.
To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience. ⋯ Long-term results with APBI using interstitial brachytherapy continue to demonstrate excellent long-term local and regional control rates and cosmetic results. According to a polymerase chain reaction-based loss of heterozygosity assay, 83% of recurrences were classified as clonally related.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2007
Randomized Controlled TrialEstimation of radiobiologic parameters and equivalent radiation dose of cytotoxic chemotherapy in malignant glioma.
To determine the radiobiologic parameters for high-grade gliomas. ⋯ The radiobiologic parameters for human high-grade gliomas can be estimated from clinical trials and could be used to inform future clinical trials, particularly combined modality treatments with newer forms of radiotherapy. Other incurable cancers should be studied using similar radiobiologic analysis.