• Rebaz A H Karim, István Vassányi, and István Kósa.
• Medical Informatics Research & Development Center, University of Pannonia, Veszprém, Hungary. Electronic address: rebaz.ahkarim@virt.uni-pannon.hu.
• Comput. Biol. Med. 2020 Oct 1; 125: 103956.

BackgroundDiabetes Mellitus outpatients would benefit from a lifestyle support tool that delivers reliable short term Blood Glucose Level (BGL) predictions.AimTo develop a method for BGL prediction based on the baseline BGL, the insulin dosing and a dietary log.MethodsA new training method is proposed for a neural network in which an absorption model is applied that uses the nutrient contents of meals. The numerical characteristics of the computed absorption curve are fed to the neural network as training inputs along with the applied insulin doses and BGL evolution measured by a Continuous Glucose Monitoring System. For comparison, another version of the training in which raw carbohydrate values are used as dietary inputs has also been implemented. The method was validated in a clinical trial with 5 patients using a total of 167 meals.ResultsIt was found that the proposed method performed significantly better on the 60- and 120-min prediction horizons, with a Root Mean Square Error of 1.12 mmol/l and 1.75 mmol/l, respectively, and more than 96% of the predicted values falling in the 'clinically acceptable' class according to clinical practice. These results surpass those published results to which our method is directly comparable, and also those of the carbohydrate-only version (1.81 mmol/l and 2.53 mmol/l).ConclusionThe integration of the absorption model in the training process has successfully contributed to the success of the model. Future research will focus on a new trial with more patients to verify these promising results.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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