• Fiona A H M Cleutjens, Martijn A Spruit, PondsRudolf W H MRWHMDepartment of Medical Psychology, Maastricht UMC+/School for Mental Health and Neurosciences (MHeNS), Maastricht, the Netherlands., VanfleterenLowie E G WLEGWDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, the Netherlands., FranssenFrits M EFMEDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, the Netherlands., Jeanette B Dijkstra, Candy Gijsen, WoutersEmiel F MEFMDepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, the Netherlands; Department of Respiratory Medicine, Maastricht UMC+, Maastricht, the Netherlands., and JanssenDaisy J ADJADepartment of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, the Netherlands..
• Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, the Netherlands. Electronic address: fionacleutjens@ciro-horn.nl.
• J Am Med Dir Assoc. 2017 May 1; 18 (5): 420-426.

ObjectivesTo compare changes in pulmonary rehabilitation (PR) dropout and outcomes between chronic obstructive pulmonary disease (COPD) patients with and without cognitive impairment.DesignA cross-sectional observational study.SettingPatients with COPD were recruited from a PR centre in the Netherlands.ParticipantsThe study population consisted of 157 patients with clinically stable COPD who were referred for and completed PR.MeasurementsA comprehensive neuropsychological examination before start of PR was administered. Changes from baseline to PR completion in functional exercise capacity [6-minute walk test (6MWT)], disease-specific health status [COPD Assessment Test (CAT) and St George's Respiratory Questionnaire-COPD specific (SGRQ-C)], psychological well-being [Hospital Anxiety and Depression Scale (HADS)], COPD-related knowledge, and their need for information [Lung Information Needs Questionnaire (LINQ)] were compared between patients with and without cognitive impairment using independent samples t tests or Mann-Whitney U tests.ResultsOut of 157 patients with COPD [mean age 62.9 (9.4) years, forced expiratory volume in the first second 54.6% (22.9%) predicted], 24 patients (15.3%) did not complete PR. The dropout rate was worse in patients with cognitive impairment compared to those without cognitive impairment (23.3% and 10.3%, P = .03). Mean changes in PR outcomes after PR did not differ between completers with and without cognitive impairment. The proportion of patients with a clinically relevant improvement in 6MWT, CAT, SGRQ-C, HADS, and LINQ scores was comparable for patients with and without cognitive impairment.ConclusionPR is an effective treatment for patients with COPD and cognitive impairment. Yet patients with cognitive impairment are at increased risk for not completing the PR program.Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

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