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Best Pract Res Clin Haematol · Sep 2003
ReviewRetinoic acid syndrome: manifestations, pathogenesis, and treatment.
- Richard S Larson and Martin S Tallman.
- Department of Pathology, University of New Mexico, Albuquerque, NM, USA. rlarson@salud.unm.edu
- Best Pract Res Clin Haematol. 2003 Sep 1; 16 (3): 453-61.
AbstractAll-trans retinoic acid (ATRA) is a potent differentiation agent that is effective therapy in acute promyelocytic leukaemia. Although ATRA is generally well tolerated, some patients develop retinoic acid syndrome. This syndrome is manifested by unexplained fever, weight gain, respiratory distress, interstitial pulmonary infiltrates, pleural and pericardial effusion, episodic hypotension, and acute renal failure. However, if identified early enough, effective therapy can be administered. This chapter discusses the clinical aspects and pathogenesis of retinoic acid syndrome.
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