Best practice & research. Clinical haematology
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Best Pract Res Clin Haematol · Sep 2003
ReviewRetinoic acid syndrome: manifestations, pathogenesis, and treatment.
All-trans retinoic acid (ATRA) is a potent differentiation agent that is effective therapy in acute promyelocytic leukaemia. Although ATRA is generally well tolerated, some patients develop retinoic acid syndrome. ⋯ However, if identified early enough, effective therapy can be administered. This chapter discusses the clinical aspects and pathogenesis of retinoic acid syndrome.