• Ann. N. Y. Acad. Sci. · Dec 2020

    Review

    Optimal preoperative neoadjuvant therapy for resectable locally advanced esophageal squamous cell carcinoma.

    • Xue-Feng Leng, Hiroyuki Daiko, Yong-Tao Han, and You-Sheng Mao.
    • Division of Thoracic Surgery, Sichuan Cancer Hospital & Research Institute, School of Medicine, University of Electronic Science and Technology of China (UESTC), Chengdu, China.
    • Ann. N. Y. Acad. Sci. 2020 Dec 1; 1482 (1): 213-224.

    AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide, especially in East Asia. ESCC accounts for more than 90% of esophageal cancer. Currently, neoadjuvant therapy in combination with surgical resection is the mainstay of treatment. However, the overall survival rate of patients with locally advanced ESCC is not satisfactory even when treated following the standard treatment guidelines. With neoadjuvant chemoradiotherapy, chemotherapy, or emerging immunotherapy, continuous exploration of efficacy in relation to ESCC is expected to improve overall survival further. Here, we review and summarize current evidence for efficacy of preoperative therapy for locally advanced ESCC.© 2020 New York Academy of Sciences.

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