• Stephanie E Combs, Anna Nikoghosyan, Oliver Jaekel, Christian P Karger, Thomas Haberer, Marc W Münter, Peter E Huber, Jürgen Debus, and Daniela Schulz-Ertner.
• Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany. Stephanie.Combs@med.uni-heidelberg.de
• Cancer. 2009 Mar 15; 115 (6): 1348-55.

BackgroundThe current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas.MethodsBetween 1997 and 2007, 394 patients were treated with carbon ion RT at Gesellschaft für Schwerionenforschung in Darmstadt, Germany. Of these patients, 17 patients were agedResultsThe median follow-up time was 49 months. Treatment was well tolerated without severe side effects and could be completed on an outpatient basis in all patients without interruptions. One patient with chordoma developed tumor progression at 60 months after carbon ion RT. All other patients demonstrated no signs of tumor progression during follow-up.ConclusionsDespite its promising outcome in children and young adults with chordomas and chondrosarcomas, further evaluation in a larger patient collective is required. Randomized studies comparing the outcome after carbon ion RT with proton RT are especially needed to evaluate the role of particle beams in the treatment of skull base tumors in children and young adults.Copyright (c) 2009 American Cancer Society.

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