-
Comput Methods Programs Biomed · Mar 2008
Classifying algorithms for SIFT-MS technology and medical diagnosis.
- K T Moorhead, D Lee, J G Chase, A R Moot, K M Ledingham, J Scotter, R A Allardyce, S T Senthilmohan, and Z Endre.
- Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. ktm19@student.canterbury.ac.nz
- Comput Methods Programs Biomed. 2008 Mar 1; 89 (3): 226-38.
AbstractSelected Ion Flow Tube-Mass Spectrometry (SIFT-MS) is an analytical technique for real-time quantification of trace gases in air or breath samples. SIFT-MS system thus offers unique potential for early, rapid detection of disease states. Identification of volatile organic compound (VOC) masses that contribute strongly towards a successful classification clearly highlights potential new biomarkers. A method utilising kernel density estimates is thus presented for classifying unknown samples. It is validated in a simple known case and a clinical setting before-after dialysis. The simple case with nitrogen in Tedlar bags returned a 100% success rate, as expected. The clinical proof-of-concept with seven tests on one patient had an ROC curve area of 0.89. These results validate the method presented and illustrate the emerging clinical potential of this technology.
Notes
Knowledge, pearl, summary or comment to share?