• Christopher G Filippi, Aaron Bos, Joshua P Nickerson, Michael B Salmela, Chris J Koski, and Keith A Cauley.
• Department of Radiology, University of Vermont School of Medicine-FAHC, 111 Colchester Ave, Burlington, VT 05401, USA. Christopher.filippi@vtmednet.org
• Pediatr Radiol. 2012 Feb 1; 42 (2): 168-74.

BackgroundOptic pathway glioma (OPG) is a characteristic hallmark of neurofibromatosis type I (NF-I).ObjectiveTo evaluate the feasibility of magnetic resonance diffusion tensor imaging (MRDTI) at 3T to detect abnormalities of the optic nerves and optic radiations in children with NF-I.Materials And Methods3-T MRDTI was prospectively performed in 9 children with NF-I (7 boys, 2 girls, average age 7.8 years, range 3-17 years) and 44 controls (25 boys, 19 girls, average age 8.1 years, range 3-17 years). Fractional anisotropy (FA) and mean diffusivity were determined by region-of-interest analysis for the optic nerves and radiations. Statistical analysis compared controls to NF-I patients.ResultsTwo NF-I patients had bilateral optic nerve gliomas, three had chiasmatic gliomas and four had unidentified neurofibromatosis objects (UNOs) along the optic nerve pathways. All NF-I patients had statistically significant decreases in FA and elevations in mean diffusivity in the optic nerves and radiations compared to age-matched controls.ConclusionMRDTI can evaluate the optic pathways in children with NF-I. Statistically significant abnormalities were detected in the diffusion tensor metrics of the optic nerves and radiations in children with NF-I compared to age-matched controls.

21 keywords...

hide…