• Kai Wang, Shi Zhao, Huling Li, Yateng Song, Lei Wang, Maggie H Wang, Zhihang Peng, Hui Li, and Daihai He.
• Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, China.
• Ann Transl Med. 2020 Jun 1; 8 (11): 689.

BackgroundSince the first appearance in Wuhan, China in December 2019, the novel coronavirus disease (COVID-19) has posed serious threats to the public health in many Chinese places and overseas. It is essential to quantify the transmissibility on real-time basis for designing public health responses.MethodsWe estimated the time-varying reproduction numbers in China, Hubei province and Wuhan city by using the renewable equation determined by the serial interval (SI) of COVID-19. We compare the average reproduction numbers in different periods of time to explore the effectiveness of the public health control measures against the COVID-19 epidemic.ResultsWe estimated the reproduction numbers at 2.61 (95% CI: 2.47-2.75), 2.76 (95% CI: 2.54-2.95) and 2.71 (95% CI: 2.43-3.01) for China, Hubei province and Wuhan respectively. We found that the reproduction number largely dropped after the city lockdown. As of February 16, the three reproduction numbers further reduced to 0.98, 1.14 and 1.41 respectively.ConclusionsThe control of COVID-19 epidemic was effective in substantially reducing the disease transmissibility in terms of the reproduction number in China reduced to 0.98 as of February 16. At the same time, the reproduction number in Wuhan was probably still larger than 1, and thus the enhancement in the public health control was recommended to maintain.2020 Annals of Translational Medicine. All rights reserved.

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