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Journal of anesthesia · Sep 1994
The effect of pentobarbital sodium on the dorsal horn of the spinal cord.
- M Nagase, K Hanaoka, M Tagami, Y Ide, T Sumida, and H Yamamura.
- Department of Anesthesiology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan.
- J Anesth. 1994 Sep 1;8(3):321-5.
AbstractThe effect of intravenously administered pentobarbital sodium on the activity of single unit in Rexed lamina V of the transected feline lumbar spinal cord was studied using an extracellular microelectrode recording technique. Pentobarbital sodium 1.0 mg·kg(-1), 2.5 mg·kg(-1), and 5.0 mg·kg(-1) administered intravenously suppressed both the spontaneous and the evoked activity in Rexed lamina V cells, known to respond principally to noxious stimuli, in a dose-dependent manner. The maximum depression of cell activity occurred within 5 min after intravenous administration. The recovery of cell activity occurred within 70 min after intravenous administration of pentobarbital sodium. We conclude that pentobarbital sodium intravenously administered has a suppressive effect on single unit activity of cells in Rexed lamina V and probably has an analgesic effect. Its suppressive effect is dose-dependent.
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