• Braz. J. Med. Biol. Res. · May 2001

    Review

    Cross-talk between neurons and glia: highlights on soluble factors.

    • F C Gomes, T C Spohr, R Martinez, and V Moura Neto.
    • Instituto de Ciências Biomédicas, Departamento de Anatomia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. fgomes@anato.ufrj.br
    • Braz. J. Med. Biol. Res. 2001 May 1; 34 (5): 611-20.

    AbstractThe development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.

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