Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas
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Braz. J. Med. Biol. Res. · May 2001
ReviewCross-talk between neurons and glia: highlights on soluble factors.
The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. ⋯ In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.