• Nippon Rinsho · Dec 2001

    Review

    [Treatment of chronic myelogenous leukemia with tyrosine kinase inhibitor].

    • R Ohno.
    • Aichi Cancer Center.
    • Nippon Rinsho. 2001 Dec 1; 59 (12): 2389-94.

    AbstractSTI571(imatinib) selectively inhibits the ABL-tyrosine kinase, the activity of which is activated by the formation of chimeric BCR/ABL. Phase I study in USA showed a remarkable effectiveness of STI571 in interferon-refractory chronic myelogenous leukemia with little adverse effects. STI571 will plausibly become the first choice drug prior to stem cell transplantation and interferon in the treatment of this leukemia.

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