• Sebastian Hinde, Tessa Crilly, Haval Balata, Rachel Bartlett, John Crilly, Phil Barber, Anthony Threlfall, Janet Tonge, Richard Booton, and Phil A Crosbie.
• Centre for Health Economics, University of York. Electronic address: sebastian.hinde@york.ac.uk.
• Lung Cancer. 2018 Dec 1; 126: 119-124.

BackgroundPrevious evaluations of low-dose CT (LDCT) lung cancer screening programmes have taken very different approaches in the design of the informative trials and the methods applied to determine cost-effectiveness. Therefore, it has not been possible to determine if differences in cost-effectiveness are due to different screening approaches or the evaluation methodology. This study reports the findings of an evaluation of the first round of a community-based, LDCT screening pilot Manchester, applying previously published methodology to ensure consistency.MethodsUsing the economic evaluation method reported in the UKLS trial, applying Manchester specific evidence where possible, we estimate the cost-effectiveness of LDCT for lung cancer. Estimates of the total costs and quality adjusted life years (QALYs) were calculated.ResultsThe Manchester programme cost £663,076, diagnosed 42 patients with lung cancer resulting in a gain in population health of 88.13 discounted life years, equivalent to 65.85 QALYs. This implied an incremental cost-effectiveness ratio of £10,069/QALY.ConclusionsWe found the Manchester programme to be a cost-effective use of limited NHS resources. The findings suggest that further research is now needed not as to whether LDCT screening is cost-effective but under what conditions can it improve patient health by the most while remaining cost-effective.Copyright © 2018 Elsevier B.V. All rights reserved.

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