• Strahlenther Onkol · Jul 1993

    Comparative Study

    Linear quadratic model--estimation of alpha/beta ratio for mucosal reaction.

    • A Chougule and S J Supe.
    • Department of Radiotherapy, R.N.T. Medical College and Hospital, Udaipur, India.
    • Strahlenther Onkol. 1993 Jul 1; 169 (7): 427-30.

    AbstractIn radiotherapy to ensure that appropriate tumor lethal dose is delivered without exceeding normal tissue tolerance, concepts like NSD and its derivatives were used in the past. Due to their short coming these concepts are now replaced by a linear quadratic model. As this model is based on the recent radiobiological data, it is claimed to be able to predict the biological responses of tumors as well as normal tissues more accurately. However, the accuracy of prediction depends on the precise values of various parameters such as alpha/beta, repair constant mu and repopulation factor that are involved in the linear quadratic model. For most of the tumors and normal tissues, values of the parameters are not yet accurately known. We have estimated alpha/beta value for mucosal reactions, i.e. normal tissue early reactions in head neck cases treated with twice daily fractionation schedules and observed it to be 7.90 Gy for slight mucositis whereas it is 7.68 and 8.11 Gy for patchy and confluent mucositis, respectively.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…