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- B J Bernstein.
- Department of Pharmacy Practice, College of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL 33328, USA. bberns@nova.edu
- Ann Pharmacother. 2000 Nov 1; 34 (11): 1332-5.
ObjectiveTo review the mechanism involved in paclitaxel-induced hypersensitivity reactions and to evaluate the potential use of docetaxel after acute hypersensitivity reactions (HSRs) to paclitaxel.Data SourcesLiterature identified through a MEDLINE search (1966-September 2000) and through secondary sources.Data SynthesisHSRs to paclitaxel can be life-threatening. The exact etiology involved in paclitaxel-induced HSRs has not been fully elucidated; the reactions may be due to the Cremophor EL vehicle or to paclitaxel itself. Options for treatment following HSRs are limited. A rechallenge attempt can be made, but is not always successful. Docetaxel, a semisynthetic taxane, may have a role in therapy for patients unable to tolerate paclitaxel therapy. This review examines the etiology of paclitaxel-induced HSRs and the potential role of docetaxel following these acute reactions.ConclusionsDocetaxel may be a viable alternative for patients who experience HSRs to paclitaxel.
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