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Hematol. Oncol. Clin. North Am. · Feb 2018
ReviewThe Peripheral Neuropathies of POEMS Syndrome and Castleman Disease.
- Michelle L Mauermann.
- Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905. Electronic address: Mauermann.Michelle@mayo.edu.
- Hematol. Oncol. Clin. North Am. 2018 Feb 1; 32 (1): 153-163.
AbstractPolyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome is a rare paraneoplastic disorder. The polyneuropathy can be the presenting symptom and is typically a painful, motor-predominant polyradiculoneuropathy often mimicking chronic inflammatory demyelinating polyradiculoneuropathy. The presence of a lambda monoclonal protein, elevated vascular endothelial growth factor, systemic features, and treatment resistance are clues to the diagnosis. Castleman disease (CD) is seen in a subset of these patients, and when present the neuropathy is similar but less severe. In contrast, in those patients with purely CD, the neuropathy is often a mild, painless distal sensory neuropathy.Copyright © 2017 Elsevier Inc. All rights reserved.
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