• Cancer investigation · Mar 2008

    Review

    "Conflict-of-interest" and participation in IRB deliberations: an alternative perspective.

    • Maurie Markman.
    • University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. mmarkman@mdanderson.org
    • Cancer Invest. 2008 Mar 1; 26 (2): 115-7.

    AbstractA natural tension exists as an IRB attempts of fulfill its mission of providing an independent and unbiased evaluation of a study while also insuring appropriate consideration of all relevant risks, benefits, and alternative strategies. IRB members with often critically relevant knowledge of unique issues involved in a protocol under review may be the individuals with the greatest potential for a perceived "conflict," due to current or past involvement in sponsor-associated research in the particular area. Management of real or perceived conflict must include full disclosure, but exclusion of such individuals from the deliberative process may result in undesirable consequences.

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