Cancer investigation
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Cancer investigation · Mar 2008
Review"Conflict-of-interest" and participation in IRB deliberations: an alternative perspective.
A natural tension exists as an IRB attempts of fulfill its mission of providing an independent and unbiased evaluation of a study while also insuring appropriate consideration of all relevant risks, benefits, and alternative strategies. IRB members with often critically relevant knowledge of unique issues involved in a protocol under review may be the individuals with the greatest potential for a perceived "conflict," due to current or past involvement in sponsor-associated research in the particular area. Management of real or perceived conflict must include full disclosure, but exclusion of such individuals from the deliberative process may result in undesirable consequences.