• Virology · Apr 2021

    Comparative Study

    The G614 pandemic SARS-CoV-2 variant is not more pathogenic than the original D614 form in adult Syrian hamsters.

    • Charles B Stauft, Christopher Z Lien, Prabhuanand Selvaraj, Shufeng Liu, and Tony T Wang.
    • Laboratory of Vector-Borne Diseases, Division of Viral Products, Office of Vaccine Research and Review, Food and Drug Administration, White Oak, MD, USA.
    • Virology. 2021 Apr 1; 556: 96-100.

    AbstractDynamic tracking of variant frequencies among viruses circulating in the global pandemic has revealed the emergence and dominance of a D614G mutation in the SARS-CoV-2 spike protein. To address whether pandemic SARS-CoV-2 G614 variant has evolved to become more pathogenic, we infected adult hamsters (>10 months old) with two natural SARS-CoV-2 variants carrying either D614 or G614 spike protein to mimic infection of the adult/elderly human population. Hamsters infected by the two variants exhibited comparable viral loads and pathology in lung tissues as well as similar amounts of virus shed in nasal washes. Altogether, our study does not find that naturally circulating D614 and G614 SARS-CoV-2 variants differ significantly in pathogenicity in hamsters.Copyright © 2021. Published by Elsevier Inc.

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