• Acta Obstet Gynecol Scand · Jan 2009

    Controlled Clinical Trial

    Discontinuation of oxytocin in the active phase of labor.

    • Bénédicte Girard, Delphine Vardon, Christian Creveuil, Michel Herlicoviez, and Michel Dreyfus.
    • Department of Obstetrics and Gynecology, University of Caen, Clémenceau Hospital, France. girard-b@chu-caen.fr
    • Acta Obstet Gynecol Scand. 2009 Jan 1; 88 (2): 172-7.

    ObjectiveTo show that early discontinuation of oxytocin will not increase the mean duration of the active labor phase in a clinically significant way.DesignControlled non-inferiority study.SettingDepartment of Obstetrics and Gynecology, University of Caen, Clemenceau Hospital, France.PopulationA total of 138 women with singleton pregnancy and a vertex presentation of over 34 gestational weeks, presenting a medical indication of induction of labor or a dystocia at onset of labor, from May 2005 to June 2006.MethodsTwo parallel groups were compared: continuation of oxytocin until delivery versus discontinuation of oxytocin at the onset of the active phase. The clinically acceptable increase in mean duration of the active phase of labor (non-inferiority margin) was set at 60 minutes.Main Outcome MeasuresPrimary outcome measure was duration of the active labor phase. Secondary outcome measures included total duration of labor, parameters concerning oxytocin use, rates of uterine hyperstimulation and fetal heart rate (FHR) abnormalities, and mode of delivery. Some neonatal outcomes were also analyzed.ResultsEquivalence of the two strategies (continuation vs. discontinuation of oxytocin) was not demonstrated (p=0.97 testing for non-inferiority), the active phase even being significantly longer by a mean of 113 minutes (p=0.0001 testing for superiority). The rates of cesarean sections, alterations of FHR and delivery hemorrhage were higher when oxytocin was continued, but not significantly. There were significantly more infants hospitalized in neonatology when oxytocin was continued (p=0.028).ConclusionsDiscontinuation of oxytocin at the onset of the active phase prolongs labor. We found no argument for discontinuing the infusion of oxytocin at the onset of the active phase.

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