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Pediatric radiology · Sep 2001
Case ReportsHerpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay.
- J W Lee, I O Kim, W S Kim, K M Yeon, H J Lee, and Y S Hwang.
- Department of Radiology, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
- Pediatr Radiol. 2001 Sep 1;31(9):619-23.
AbstractHerpes simplex virus (HSV) type I causes a fulminant necrotising meningoencephalitis distinguished from other encephalitides by its focal and often haemorrhagic nature. Specific antiviral therapy with acyclovir can significantly improve the prognosis. We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling, high signal intensity on T2-weighted images in the subfrontal region, temporal lobe and insula in the initial stage, then regional extension with enhancement and haemorrhage despite appropriate acyclovir therapy, and finally encephalomalacia and brain atrophy.
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