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- P Sutton.
- School of Microbiology and Immunology, University of New South Wales, NSW 2052, Sydney, Australia.
- Vaccine. 2001 Mar 21; 19 (17-19): 2286-90.
AbstractThis review discusses recent progress in the development of a vaccine against Helicobacter pylori. This progress includes demonstration that: effective immunisation is independent of antibodies but dependent upon CD4+ T helper cells, although their role remains unknown; the immunisation regime can be improved to increase efficacy; successful immunisation against H. pylori is possible using a live vector; a strain of H. pylori suitable for experimental infection of humans has been developed. Important issues that remain to be addressed include incomplete protection, non-availability of suitable mucosal adjuvants and post-immunisation gastritis. Significantly, commercial development of products for clinical trial is underway.
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