• Karthik Chary, Mikko J Nissi, Olli Nykänen, Eppu Manninen, Ramón I Rey, Karin Shmueli, Alejandra Sierra, and Olli Gröhn.
• A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
• NMR Biomed. 2021 Feb 1; 34 (2): e4438.

AbstractThe primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic phase. The aim of this study was, therefore, to investigate variations in the susceptibility distribution related to these secondary tissue changes in a rat model after severe lateral fluid percussion injury. We compared quantitative susceptibility mapping (QSM) and R2 * measurements with histological analyses in white and grey matter areas outside the primary lesion but connected to the lesion site. We demonstrate that susceptibility variations in white and grey matter areas could be attributed to reduction in myelin, accumulation of iron and calcium, and gliosis. QSM showed quantitative changes attributed to secondary damage in areas located rostral to the lesion site that appeared normal in R2 * maps. However, combination of QSM and R2 * was informative in disentangling the underlying tissue changes such as iron accumulation, demyelination, or calcifications. Therefore, combining QSM with R2 * measurement can provide a more detailed assessment of tissue changes and may pave the way for improved diagnosis of TBI, and several other complex neurodegenerative diseases.© 2020 John Wiley & Sons, Ltd.

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