• Carmen G Torres-Alarcón, Antonio García-Ruíz, Cesar R Cañete-Ibáñez, Irving I Morales-Pogoda, Carlos M Muñoz-Arce, Blanca E Cid-Domínguez, Maribel Montalvo-Bárcenas, Guadalupe Maza-de la Torre, Chantal Sandoval-López, Emanuel Gaytán-Guzmán, and José D Correo-Zamora.
• Blood Bank Department.
• Gac Med Mex. 2021 Jan 1; 157 (2): 174-180.

IntroductionWhether there is an influence of the ABO blood system on SARS-CoV-2 infection is unknown.ObjectiveTo analyze if there is an association between the ABO system antigens and susceptibility to and severity of SARS-CoV-2 infection.Material And MethodsThe frequency of ABO system antigens was compared in 73 confirmed cases of SARS-CoV-2 infection and 52 clinically healthy donors. Infection severity was assessed by comparing the frequency of antigens by disease severity and mortality.ResultsThe risk of suffering from SARS-CoV-2 infection increases in subjects with A vs. non-A antigen (OR = 1.45; 95 % CI: 1.061-1.921). Blood phenotype O reduces the risk of SARS-CoV-2 infection (OR = 0.686; 95 % CI: 0.522-0.903). No differences were found regarding disease severity. In critically ill patients, the risk of mortality increased in subjects with A vs. non-A antigen (OR = 3.34; 95 % CI: 1.417-8.159).ConclusionBlood group A is a risk factor for SARS-CoV-2 infection, but not for disease severity, although in critically ill patients it is a risk factor for mortality.Copyright: © 2021 Permanyer.

28 keywords...

hide…