• Xiaofen Ma, Shumei Li, Junzhang Tian, Guihua Jiang, Hua Wen, Tianyue Wang, Jin Fang, Wenfeng Zhan, and Yikai Xu.
• Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China.
• Clin Neurophysiol. 2015 Jun 1; 126 (6): 1190-1197.

ObjectiveWe aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain.MethodsWith fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions.ResultsIBS patients showed decreased ALFF values in the left superior frontal gyrus, right hippocampus, right middle frontal gyrus, bilateral postcentral, and right superior temporal pole, while increased ALFF values in the left median cingulate and left calcarine. There was significant correlation between ALFF values in the altered regions and duration of disease in IBS. FC analysis revealed the increased connectivity between cingulate and frontal cortex in IBS.ConclusionsOur findings could provide both regional and brain connectivity spontaneous neuronal activity properties in IBS.SignificanceOur study may lead to a better understanding of intrinsic functional architecture of brain activity in IBS and highlight the potential for using the ALFF and FC metrics as a disease biomarker.Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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