• Journal of neuro-oncology · Mar 2004

    Clinical Trial

    Non-resectable slow-growing meningiomas treated by hydroxyurea.

    • David Loven, Ruth Hardoff, Zvi Bar Sever, Adam P Steinmetz, Michael Gornish, Zvi H Rappaport, Eyal Fenig, Zvi Ram, and Aaron Sulkes.
    • Institute of Oncology, Ha'Emek Medical Center, Afula, Israel. loven_da@clalit.org.il
    • J. Neurooncol. 2004 Mar 1; 67 (1-2): 221-6.

    PurposeTo test the benefit of hydroxyurea in the treatment of recurrent and non-resectable slow-growing meningiomas.MethodsTwelve patients with regrowing non-malignant meningiomas, were enrolled for a protocol of 2 years with continuous chemotherapy with hydroxyurea, 20 mg/kg/day. Response to treatment was evaluated both clinically and by diagnostic imaging using computed tomography (CT) and 201-Thallium single photon emission CT. One minimal response was documented by CT, accompanied by clinical stabilization. Nine patients showed progressive disease, at least by one imaging procedure, with a median time to progression of 13 months (range 4-24). Two other patients were not available for response due to early removal from the study, following abrupt manifestation of grades 3-4 hematological toxicity.ConclusionIn this series hydroxyurea has not shown effectiveness in the treatment of non-resectable slow-growing meningiomas: neither for achieving response, nor for arresting disease progression.

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