Journal of neuro-oncology
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Journal of neuro-oncology · Mar 2004
Comparative StudyPosterior fossa metastases: risk of leptomeningeal disease when treated with stereotactic radiosurgery compared to surgery.
Leptomeningeal disease (LMD) represents a diffuse form of central nervous system metastatic disease that is often associated with poor quality of life and prognosis. Our objective was to compare the incidence of LMD in patients with posterior fossa metastases (PFM) following stereotactic radiosurgery (SRS) versus surgical resection. ⋯ In this retrospective analysis of patients with PFM, SRS was associated with a lower incidence of LMD than was surgery. Although LMD was associated with rapid and considerable decline in the quality of life, it did not influence the overall survival. SRS was associated with less serious complications than surgery. Surgery in this study was performed on patients with larger lesion sizes and a trend toward poorer initial performance status, which could bias these results. A prospective study directly comparing surgery and SRS and further evaluating the significance of LMD in PFM is warranted.
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Journal of neuro-oncology · Mar 2004
Clinical TrialNon-resectable slow-growing meningiomas treated by hydroxyurea.
To test the benefit of hydroxyurea in the treatment of recurrent and non-resectable slow-growing meningiomas. ⋯ In this series hydroxyurea has not shown effectiveness in the treatment of non-resectable slow-growing meningiomas: neither for achieving response, nor for arresting disease progression.